Engineering a Multilayered Skin Equivalent: The Importance of Endogenous Extracellular Matrix and Model Flexibility for Nuanced and Accurate Skin Studies
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L Smith, V Maltman, P De Los Santos Gomez…
Skin Tissue Engineering …, 2025
Springer
Human skin equivalents (HSEs) are a valuable tool for both academic and industrial laboratories to further the understanding of skin physiology in a range of health and disease situations. There have been many advances in the development of HSEs that successfully recapitulate the structure of human skin in vitro; however a main limitation is variability due to the use of complex protocols and exogenous extracellular matrix (ECM) proteins. Previously, we have developed a robust, reproducible, and unique full thickness HSE, using …
