Engineering a Pigmented Skin Equivalent That Is Responsive to External Stimuli
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P De Los Santos Gomez, K Goncalves…
Skin Tissue Engineering …, 2025
Springer
Recently, dermatological research has more widely adopted the use of human skin equivalents (HSEs) to better recreate skin structure and function in vitro, which can act as a preclinical tool. However, many popular HSEs contain only two main cell types: keratinocytes and fibroblasts to model epidermal and dermal compartments respectively. This lack of supporting cell types can be associated with a wide range of limitations, most notably an inaccurate representation of skin's innate response to exogenous stressors such …
