期刊论文Humanized CRBN knockin mice enable in vivo assessment the efficacy and toxicity of CRBN-targeted protein degraders复制

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Y Li, X Qiu, L Feng, D Feng, R Sun
Cancer Research, 2025
aacrjournals.org
Protein degraders have emerged as a transformative therapeutic approach in the past decade, enabling targeted degradation of proteins, including traditionally undruggable targets, by facilitating the recruitment of E3 ubiquitin ligases. Among these, molecular glues such as thalidomide and its derivatives, and PROteolysis TArgeting Chimeras (PROTACs), have gained significant attention. Cereblon (CRBN), a key component of the Cullin 4 RING E3 ubiquitin ligase (CRL4), is the most extensively studied target in protein degrader …