Sensory neuron sodium channel Nav1.8 is essential for pain at low temperatures
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K Zimmermann, A Leffler, A Babes, CM Cendan…
Nature, 2007
nature.com
… human limbs cool down, but pain perception persists and cold-… In contrast, the inactivation
properties of Na v 1.8 are entirely cold… Thus, in the cold, Na v 1.8 remains available as the sole …

