Xanomeline: a selective muscarinic agonist for the treatment of Alzheimer's disease
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FP Bymaster, CA Whitesitt, HE Shannon…
Drug Development …, 1997
Wiley Online Library
Xanomeline is a novel muscarinic receptor agonist relatively devoid of parasympathomimetic side effects. Xanomeline had high affinity for muscarinic receptors and much lower affinity for a variety of other neuronal receptors in radioligand binding assays. Functional studies in cell lines transfected with the muscarinic receptor subtypes demonstrated that xanomeline had higher potency and efficacy for m1 and m4 receptors than m2, m3, and m5 receptor subtypes. Similarly, in isolated tissue studies, xanomeline had …
