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YN1548: A novel small-molecule agonist of human glucagon-like peptide-1 receptor for the treatment of type 2 diabetes mellitus and obesity复制

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IG Je, TK Kim, HJ Lee, MY Lee, KM An, JT Park…
European Journal of …, 2025
Elsevier
Type 2 diabetes mellitus (T2DM) and obesity are the major global health concerns. Glucagon-like peptide-1 (GLP-1) receptor agonists are effective incretin-based treatments for T2DM and obesity. The patient compliance of peptide-based GLP-1 receptor agonists is limited due to subcutaneous administration. This study aimed to develop small-molecule GLP-1 receptor agonists that can be administered orally. Pharmacological properties of YN1548 were evaluated using in vitro assays in Chinese hamster ovary (CHO) cells …

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