Coordinated Reinforcement of Energy and Ammonia-Donor Supply Enhances L-Histidine Production in Escherichia coli
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ZY Chen, Q Sheng, X Dong, C Gao, XM Li, GP Hu…
Food Bioscience, 2026
Elsevier
L-histidine is a high-value amino acid widely used in the food, pharmaceutical, and additive industries. However, efficient production of L-histidine in Escherichia coli remains challenging because its biosynthesis requires substantial precursor, energy, and ammonia-donor supply. In this study, the L-histidine biosynthetic pathway and the pentose phosphate pathway were optimized to construct strain His20. During late-stage fermentation, elevating dissolved oxygen and supplementing monosodium glutamate or glutamine hydrochloride …
