PRAX-114 Produces Robust Increases in EEG Beta Frequency Power, a Translational Biomarker of GABA-A Receptor Modulation, Without Dose-Limiting …
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Z Hughes, S Raines, L Scott…
Biological …, 2021
biologicalpsychiatryjournal.com
Background PRAX-114 is a GABA-A receptor positive allosteric modulator (GABAA-R-PAM) neuroactive steroid which achieves preferential potentiation of extrasynaptic GABAAR compared to synaptic GABAAR. GABAAR-PAMs cause increases in EEG β-frequency band power. The effects of PRAX-114 on quantitative EEG (qEEG) were measured in rodents and healthy human volunteers. Methods The effects of PRAX-114 (0.3-10mg/kg ip) on rat qEEG were measured in male SD rats fitted with EEG leads connected to a telemetry device in a …
