The effects of programmed administration of human parathyroid hormone fragment (1–34) on bone histomorphometry and serum chemistry in rats
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H Dobnig, RT Turner
Endocrinology, 1997
academic.oup.com
PTH treatment can result in dramatic increases in cancellous bone volume in normal and osteopenic rats. However, this potentially beneficial response is only observed after pulsatile treatment; continuous infusion of PTH leads to hypercalcemia and bone abnormalities. The purpose of these studies was to determine the optimal duration of the PTH pulses. A preliminary study revealed that human PTH-(1–34)(hPTH) is cleared from circulation within 6 h after sc administration of an anabolic dose of the hormone (80μ g/kg). To establish the …
