Treatment of vulvovaginal candidiasis with a 500-mg vaginal tablet of clotrimazole.
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D Hughes, T Kriedman
Clinical Therapeutics, 1984
europepmc.org
A prospective, randomized, double-blind trial compared the efficacy and safety of a new one-dose clotrimazole regimen and placebo. Twenty-six patients with clinically and mycologically proven vulvovaginal candidiasis received either a 500-mg tablet of clotrimazole or a placebo. Follow-up visits were performed approximately one week and one month after treatment. Efficacy was evaluated in 23 patients. There was a highly significant difference in clinical and mycological responses to the two regimens (P= 0.0001, Fisher