Physiological Assessment of Coronary Artery Disease
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A Randles
New England Journal of Medicine, 2026
ovid.com
In this issue of the Journal, Fearon et al. 1 report the results of the Advancing Cath Lab Results with FFRangio Coronary Physiology Assessment (ALL-RISE) trial, a large, multicenter, randomized, noninferiority trial evaluating whether fractional flow reserve (see Key Concepts) derived directly from coronary angiography (FFRangio) can guide percutaneous coronary intervention (PCI) with outcomes similar to those achieved with the use of pressure wire–based assessment (Fig. 1). The trial tests a pragmatic premise: if …
