期刊论文Synthesis and pharmacological study of some new beta-(dialkylaminomethyl)-gamma-butyrolactones and their tetrahydrofuran analogues.复制

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GB Foscolos, N Kolocouris, G Fytas…
Farmaco (Societa …, 1996
europepmc.org
This paper describes the synthesis of beta-(dialkylaminomethyl)-gamma-butyrolactones (6 and 15) and their tetrahydrofuran analogs 7 and 16. Their convulsant activity was studied on mice and could display an antiGABAergic component, but, unlike the alpha-(dialkylaminomethyl)-gamma-butyrolactones, no antiglycinergic component was detected. The possibility of an activation of the glutamatergic receptors (NMDA), by indirect stimulation of their glycinergic site, by the tetrahydrofurans analogs 7 could be considered. These …