Factors influencing the immunogenicity and Immunotoxicity of cyclic RGD peptide-modified Nanodrug delivery systems
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X Wang, N Meng, S Wang, L Lu, H Wang…
Molecular …, 2020
ACS Publications
c (RGDyK)-modified liposomes have been shown to be immunogenic and potentially trigger acute systemic anaphylaxis upon repeated intravenous injection in both BALB/c nude mice and ICR mice. However, questions concerning the potential influence of mouse strains, immunization routes, drug carrier properties, and changes in c (RGDyK) itself on the immunogenicity and resultant immunotoxicity (anaphylaxis) of cyclic RGD peptide-modified nanodrug delivery systems remain unanswered. Here, these potential impact factors were …
