期刊论文[Effect of diet on the pharmacokinetics of tebipenem pivoxil fine granules in healthy male volunteers]复制

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文献链接: https://pubmed.ncbi.nlm.nih.gov/19673355复制

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PMID: 19673355
作者: Mitsuyoshi Nakashima; Jun Morita; Toshihiko Takata; Kazumasa Aizawa; Mitsuyoshi Nakashima; ...
摘要: Tebipenem pivoxil (TBPM-PI), a novel oral carbapenem antibiotic, is a prodrug of tebipenem (TBPM). We assessed the pharmacokinetics of TBPM-PI fine granules at 250 mg as potency in healthy male volunteers in fasting and non-fasting states. Cmax of TBPM in the non-fasting state was lowered to approximately 60% of that in the fasting state, however AUC(0-infinity) and urinary excretion of TBPM in the non-fasting state were almost equivalent to those in the fasting state when TBPM-PI fine granules ...